Melt butter over medium heat and add lump crab meat and cajun seasoning, onion powder, garlic powder, and paprika. Saute for 3-4 minutes and set aside.
In a large mixing bowl, add mayo, cream cheese, lemon zest, lemon juice, worcestershire sauce, grated cheddar cheese, and chives. Add in your hot crab and mix thoroughly until combined. Season with salt and pepper to taste.
Add mixture to a 20 oz baking dish and top with more cheddar cheese. Bake at 350F for 15 minutes then broil for 2-3 minutes until golden brown. Serve with vegetables/crackers/bread of your choice & enjoy!